Intravenous infusion of human derived gammaglobulin is one of the most effective therapies in neuromuscular disorders. The infusion is given in a dose of 2gms/kg/BWT over 2-5 days. Our center is equipped with an infusion area and registered nurse who is familiar with the administration and complication of this therapy.
Intravenous immunoglobulin (IVIG) is proven to be effective in the following neuromuscular disorders:
- Guillain-Barré syndrome
- Chronic inflammatory demyelinating polyneuropathy
- Multifocal motor neuropathy
- Stiff-person syndrome
- Myasthenia gravis
- Lambert-Eaton myasthenic syndrome.
There are several mechanisms of action for IVIG.
- It modulates the expression and function of Fc receptors.
- It interferes with the activation of complement and production of cytokines.
- It provides anti-idiotypic antibodies.
It affects the activation and effector functions of T and B cells.